Clinical Trial Research Guides & Intelligence 2026

Independent research guides, expert analysis, and 10,000+ live recruiting trials — sourced daily from ClinicalTrials.gov. Free access for patients, caregivers, and researchers.

🟢 LIVE // 10,000 Active Trials // Updated Daily

ClinicalMetric is an independent editorial resource that helps patients, caregivers, and researchers make sense of clinical trials. Every year thousands of studies open across the United States, but the official registries are written for medical professionals — dense eligibility criteria, technical endpoints, and acronyms that are hard to parse when you or a family member are facing a diagnosis. Our role is to translate that information into plain-language guidance you can actually use: what a trial is, how phases differ, what questions to ask before enrolling, and how to weigh the risks and benefits of participation.

We publish in-depth research guides on specific conditions — from cancer and diabetes to rare and autoimmune diseases — alongside practical patient guides covering informed consent, compensation, placebos, and your rights as a participant. All trial data is sourced directly from ClinicalTrials.gov and refreshed daily, while our editorial content is written and reviewed by the ClinicalMetric team. We are not affiliated with any sponsor or recruiter, and nothing here is medical advice; our goal is simply to make clinical research easier to understand so you can have a more informed conversation with your own doctor.

Medical Disclaimer: ClinicalMetric is an informational platform only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendation. Always consult a qualified healthcare professional before making any medical decision or enrolling in a clinical trial. Full disclaimer →

Live Recruiting Clinical Trials

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Data sourced from ClinicalTrials.gov — updated daily.

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◆ FEATURED RESEARCH GUIDE NEW By the ClinicalMetric Editorial Team · 2026
Original Research  ·  IN-DEPTH GUIDE
Why Clinical Trials Fail: An Analysis of 50,541 Terminated and Withdrawn Studies
ClinicalMetric analysed every terminated and withdrawn study on ClinicalTrials.gov. Trials rarely die from science. 36.7% die because nobody enrolled — and academic centres fail three times more often than industry.
Read Full Guide →
Patient Guide Adverse Events Explained: How Side Effects Are Tracked, Graded, and Reported What happens when you report a side effect in a clinical trial? A guide to how adverse events are defined, graded by severity (CTCAE), judged for relatedness, and reported to the FDA and safety boards — and what your role is. Read guide → Trial Design Randomization and Blinding: Why Trials Keep You (and Your Doctor) in the Dark Why do clinical trials use randomization and blinding? A plain-language explanation of how random assignment and masking remove bias, what single- and double-blind mean, and what it means for you as a participant. Read guide → Patient Guide After a Trial Closes: Results Reporting, Continued Access and Follow-Up Obligations When a clinical trial closes, what happens next? A guide to post-trial drug access, open-label extensions, when and where results are published, safety follow-up, and your right to know the outcome. Read guide → Patient Guide The Real Cost of Joining a Clinical Trial: What Insurance Covers and What You Pay A clear breakdown of clinical trial costs — what the sponsor pays for, what your insurance is legally required to cover under the ACA, what routine care means, and the hidden out-of-pocket expenses patients underestimate. Read guide → Patient Guide Compassionate Use and Expanded Access: Getting an Investigational Drug Outside a Trial How expanded access (compassionate use) lets seriously ill patients obtain an investigational drug outside a clinical trial — who qualifies, how the FDA request works, what it costs, and how it differs from Right to Try. Read guide → Immuno-Oncology Bispecific Antibodies in Cancer Clinical Trials 2026: Six Approvals, T-Cell Engagers, and the Solid Tumor Question Six bispecific antibodies are FDA-approved. Teclistamab shows 63% ORR in triple-class refractory myeloma. Glofitamab achieves complete responses in DLBCL. The solid tumor pipeline and what step-up dosing solved. Read guide →
VIEW ALL 117 RESEARCH GUIDES →

UNDERSTANDING CLINICAL TRIALS

What Is a Clinical Trial?

A clinical trial is a research study conducted in people to evaluate a medical intervention — a drug, device, procedure, or behavioral change. All trials are registered on ClinicalTrials.gov before enrollment begins, as required by U.S. law (FDAAA 801). Trials are classified by phase: Phase 1 tests safety in small groups, Phase 2 tests efficacy, Phase 3 compares to existing treatments in large populations, and Phase 4 monitors long-term effects after approval.

Read full guide →
Who Can Participate?

Every trial defines inclusion and exclusion criteria — the specific requirements a participant must meet. Common factors include age range, diagnosis, disease stage, prior treatments, and current medications. Eligibility criteria exist to protect patient safety and ensure valid scientific results. You can review the full criteria for any trial on its ClinicalTrials.gov registry page before contacting the study team.

Read eligibility guide →
Are Participants Paid?

Compensation varies widely by trial type, duration, and sponsor. Phase 1 trials (healthy volunteers) often pay $1,000–$5,000 for inpatient stays. Later-phase trials for patients with specific conditions typically reimburse travel and time costs rather than paying a flat fee. FDA guidance requires that payment not be so high as to be coercive. Always review the informed consent document for specific payment terms before enrolling.

Read compensation guide →

POPULAR RESEARCH GUIDES

ALL 117 GUIDES →
Guide How to Join a Clinical Trial Oncology Cancer Clinical Trials 2026 Process Eligibility Criteria Explained Patients Clinical Trial Pay & Compensation Neurology Alzheimer's Trials 2026 Research Phase 1 vs Phase 3 Trials Timeline How Long Do Trials Take? Basics What Is a Clinical Trial? Gastro Crohn's Disease Trials 2026 Gastro Ulcerative Colitis Trials 2026 Neurology Multiple Sclerosis Trials 2026 Psychiatry Schizophrenia Trials 2026 Oncology Thyroid Cancer Trials 2026

RESEARCH FUNDING & GRANT DEADLINES 2026

Deadlines, due dates, and application strategy for the major clinical research funding mechanisms — updated for the 2026 cycle.

NIH NIH R01 Grant Deadlines & Due Dates NIH NIH R03 & R21 Small Grant Deadlines PCORI PCORI Funding Deadlines NCI NCI Community Oncology Deadlines BARDA BARDA Funding Opportunities Funding NIH-Funded Clinical Research Guide

In-Depth Research Guides by Condition

Expert guides on trials, treatments, and eligibility for the most-researched conditions

All Guides →
🔬 Cancer💉 Diabetes🧠 Alzheimer's💬 Depression❤️ Heart Disease🧬 Parkinson's🫀 Multiple Sclerosis🔭 Leukemia🦠 COVID-19🩺 HIV/AIDS
Editorial Standards All content reviewed by the ClinicalMetric Editorial Team — specialists in clinical research, medical data, and trial protocol analysis.
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What Are Clinical Trials?

Clinical trials are carefully designed research studies that evaluate new medical treatments, drugs, devices, or behavioral interventions in human volunteers who meet defined eligibility criteria. These studies follow a strict scientific protocol approved by an independent ethics board before any recruiting of participants begins.

Live recruiting studies listed on ClinicalTrials.gov represent the most current opportunities for patients and healthy volunteers to participate in cutting-edge medical research across hundreds of conditions worldwide. ClinicalMetric organizes these studies so researchers, patients, and healthcare professionals can find relevant trials quickly.

How to Find the Right Trial

Finding the right clinical trial begins with identifying your condition, location preferences, and the phase of research you are comfortable joining. Earlier phases carry more uncertainty while later phases involve well-characterized interventions already studied in many participants.

Each trial listing includes eligibility criteria specifying the required age range, diagnosis, prior treatment history, and any exclusion factors. Reviewing these details carefully before contacting the study team saves time for everyone involved in the screening process.

Understanding Trial Phases

Clinical trials progress through four standardized phases. Phase 1 studies enroll 20–80 participants primarily to evaluate safety and dosing. Phase 2 expands to 100–300 participants and tests therapeutic effect. Phase 3 compares the new intervention against standard-of-care treatments across thousands of participants. Phase 4 studies occur after regulatory approval and monitor long-term safety in the general population.

FREQUENTLY ASKED QUESTIONS

What is ClinicalMetric? +

ClinicalMetric is an independent clinical trial intelligence platform tracking 400,000+ active clinical trials worldwide, sourced daily from ClinicalTrials.gov (NIH/NLM). It provides condition-based filtering, phase breakdowns, eligibility summaries, and sponsor data to help patients, caregivers, and researchers find relevant studies.

Is ClinicalMetric affiliated with NIH, the FDA, or any pharmaceutical company? +

No. ClinicalMetric is an independent, privately operated platform. We are not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. We do not recruit for trials or receive referral fees from trial sponsors.

How do I join a clinical trial? +

To join a trial, review the eligibility criteria on the trial's detail page — including age range, diagnosis requirements, and exclusion factors. Then contact the study coordinator using the information listed on ClinicalTrials.gov. Your physician can also review your case and provide a referral to a specific study.

Is information on ClinicalMetric medical advice? +

No. All information on ClinicalMetric is for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here. Always consult a qualified healthcare professional before considering trial participation.

How often is clinical trial data updated? +

Trial data is sourced from ClinicalTrials.gov and refreshed daily. ClinicalMetric uses a multi-tier caching system to serve current data while maintaining fast, globally distributed performance.

Latest Research Intelligence

View all 117 guides →
Original Research
Why Clinical Trials Fail: An Analysis of 50,541 Terminated and Withdrawn Studies
ClinicalMetric analysed every terminated and withdrawn study on ClinicalTrials.gov. Trials rarely die from science. 36.7% die because nobody enrolled — and academic centres fail three times more often than industry.
Read guide →
Patient Guide
Adverse Events Explained: How Side Effects Are Tracked, Graded, and Reported
What happens when you report a side effect in a clinical trial? A guide to how adverse events are defined, graded by severity (CTCAE), judged for relatedness, and reported to the FDA and safety boards — and what your role is.
Read guide →
Trial Design
Randomization and Blinding: Why Trials Keep You (and Your Doctor) in the Dark
Why do clinical trials use randomization and blinding? A plain-language explanation of how random assignment and masking remove bias, what single- and double-blind mean, and what it means for you as a participant.
Read guide →
Patient Guide
After a Trial Closes: Results Reporting, Continued Access and Follow-Up Obligations
When a clinical trial closes, what happens next? A guide to post-trial drug access, open-label extensions, when and where results are published, safety follow-up, and your right to know the outcome.
Read guide →
Patient Guide
The Real Cost of Joining a Clinical Trial: What Insurance Covers and What You Pay
A clear breakdown of clinical trial costs — what the sponsor pays for, what your insurance is legally required to cover under the ACA, what routine care means, and the hidden out-of-pocket expenses patients underestimate.
Read guide →
Patient Guide
Compassionate Use and Expanded Access: Getting an Investigational Drug Outside a Trial
How expanded access (compassionate use) lets seriously ill patients obtain an investigational drug outside a clinical trial — who qualifies, how the FDA request works, what it costs, and how it differs from Right to Try.
Read guide →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology